Sugi Predict

Sugi Predict / Compounds / SCHEMBL148202

SCHEMBL148202

SCHEMBL148202

O=C(O)c1ccc(Br)c2c3c([nH]c12)CCCC3

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GFER P55789 1/20 0.57
▸ HSD17B10 Q99714 4/20 0.44
▸ MAPT P10636 3/20 0.44
▸ ALOX15 P16050 2/20 0.44
▸ MAPK1 P28482 2/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ IKBKB O14920 1/20 0.44
▸ USP2 O75604 1/20 0.44
▸ TP53 P04637 1/20 0.44
▸ MAPK10 P53779 1/20 0.44
▸ CASP1 P29466 1/20 0.43
▸ CASP7 P55210 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ BTK Q06187 6/20 0.38
▸ ADRA2A P08913 1/20 0.37
▸ CLCN2 P51788 1/20 0.37
▸ EGFR P00533 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL150083 0.87 HSD17B10 (0.58) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL11742569 0.84 GFER (0.58) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL11732994 0.82 GFER (0.57) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL24191951 0.81 GFER (0.41) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL24192045 0.81 GFER (0.41) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL30160170 0.81 GFER (0.40) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL30159806 0.81 GFER (0.40) GFERHSD17B10MAPTALOX15MAPK1
Hydrochloric Acid SCHEMBL31239283 0.78 HTR1B (0.41) GFERHSD17B10MAPTALOX15MAPK1
SCHEMBL30240146 0.77 GFER (0.37) GFERADRA2ACLCN2
SCHEMBL30240148 0.77 GFER (0.37) GFERADRA2ACLCN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11053197-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-06 — — US disclosed
US-11053197-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-06 — — US disclosed
US-20200255377-A1 CARBAZOLE DERIVATIVES Organization Name: BRISTOL-MYERS SQUIBB COMPANY (US) 2020-08-13 — — US disclosed
US-20200255377-A1 CARBAZOLE DERIVATIVES Organization Name: BRISTOL-MYERS SQUIBB COMPANY (US) 2020-08-13 — — US disclosed
US-10676434-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-09 — — US disclosed
US-10676434-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-09 — — US disclosed
EP-3209651-B9 CARBAZOLE DERIVATIVES BRISTOL MYERS SQUIBB CO (US) 2020-05-20 — — EP disclosed
EP-3209651-B9 CARBAZOLE DERIVATIVES BRISTOL MYERS SQUIBB CO (US) 2020-05-20 — — EP disclosed
CN-107074804-B Carbazole derivatives 百时美施贵宝公司 2020-02-18 — — CN disclosed
EP-3209651-B1 CARBAZOLE DERIVATIVES BRISTOL MYERS SQUIBB CO (US) 2019-10-23 — — EP disclosed
US-10266491-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2019-04-23 — — US disclosed
US-10266491-B2 Carbazole derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 2019-04-23 — — US disclosed
US-20170362176-A1 CARBAZOLE DERIVATIVES BRISTOL-MYERS SQUIBB COMPANY (US) 2017-12-21 — — US disclosed
US-20170362176-A1 CARBAZOLE DERIVATIVES BRISTOL-MYERS SQUIBB COMPANY (US) 2017-12-21 — — US disclosed
EP-3209651-A1 CARBAZOLE DERIVATIVES Bristol-Myers Squibb Company (US) 2017-08-30 — — EP disclosed
EP-2391602-B1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2013-12-04 — — EP disclosed
US-8362065-B2 Carbazole carboxamide compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-01-29 — — US disclosed
US-20120058996-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-8084620-B2 Carbazole carboxamide compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2011-12-27 — — US disclosed
US-20100160303-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-06-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058996-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, FLT3, JAK1 GFER 4365/4885HSD17B10 3992/4885MAPT 4223/4885
US-10266491-B2 Carbazole derivatives BTK, SYK, JAK2 GFER 3800/4885HSD17B10 4204/4885MAPT 4428/4885
US-10676434-B2 Carbazole derivatives BTK, SYK, JAK2 GFER 3620/4885HSD17B10 4222/4885MAPT 4523/4885
US-20100160303-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, FLT3, JAK1 GFER 4365/4885HSD17B10 3992/4885MAPT 4223/4885
US-20170362176-A1 CARBAZOLE DERIVATIVES BTK, SYK, JAK2 GFER 3800/4885HSD17B10 4204/4885MAPT 4428/4885
US-11053197-B2 Carbazole derivatives BTK, SYK, JAK2 GFER 3620/4885HSD17B10 4222/4885MAPT 4523/4885
US-20200255377-A1 CARBAZOLE DERIVATIVES BTK, SYK, JAK2 GFER 3620/4885HSD17B10 4222/4885MAPT 4523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.