Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403589 | 0.87 | HDAC1 (1.00) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL1403587 | 0.87 | HDAC1 (1.00) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5050276 | 0.87 | HDAC1 (1.00) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL1403173 | 0.83 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL1403302 | 0.83 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL1403301 | 0.83 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL1403177 | 0.83 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5020762 | 0.82 | HDAC1 (0.76) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL25212501 | 0.77 | MAOB (0.68) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL14820600 | 0.76 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2573069-A2 | Inhibitors of histone deacetylase and prodrugs thereof | MethylGene Inc. (CA) | 2013-03-27 | — | — | EP | disclosed |