Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986357 | 0.87 | HDAC1 (0.96) | HDAC1HDAC8HDAC3HSP90AA1HDAC6 | |
| SCHEMBL4580313 | 0.86 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HSP90AA1HDAC6 | |
| SCHEMBL1981700 | 0.84 | HDAC8 (1.00) | HDAC1HDAC8HDAC3NPC1RAB9A | |
| SCHEMBL10094807 | 0.81 | HDAC1 (0.73) | HDAC1HDAC8NPC1RAB9AHSP90AA1 | |
| SCHEMBL5020665 | 0.79 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC6HDAC2 | |
| SCHEMBL1980515 | 0.79 | RARB (0.65) | HDAC1HDAC8HDAC3NPC1RAB9A | |
| SCHEMBL14418978 | 0.78 | HDAC1 (0.64) | HDAC1HDAC8HDAC3NPC1RAB9A | |
| SCHEMBL16438824 | 0.78 | HDAC3 (0.68) | HDAC1HDAC8HDAC3NPC1RAB9A | |
| SCHEMBL9109405 | 0.77 | HDAC3 (0.80) | HDAC1HDAC8HDAC3NPC1RAB9A | |
| SCHEMBL2743520 | 0.77 | HDAC1 (0.68) | HDAC1HDAC8HDAC3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2573069-A2 | Inhibitors of histone deacetylase and prodrugs thereof | MethylGene Inc. (CA) | 2013-03-27 | — | — | EP | disclosed |