Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 19/20 | 0.58 |
| ▸ | CTSK | P43235 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081644 | 1.00 | CTSC (0.58) | CTSCCTSKKCNH2GPR119 | |
| SCHEMBL16071153 | 0.95 | CTSC (0.59) | CTSCCTSKKCNH2GPR119 | |
| SCHEMBL19187574 | 0.94 | CTSC (0.51) | CTSCCTSKKCNH2 | |
| SCHEMBL15081691 | 0.94 | CTSC (0.51) | CTSCCTSKKCNH2 | |
| SCHEMBL16078802 | 0.92 | CTSC (0.58) | CTSCCTSK | |
| SCHEMBL15081649 | 0.92 | CTSC (0.57) | CTSCCTSK | |
| SCHEMBL15081653 | 0.91 | CTSC (0.58) | CTSCCTSKKCNH2 | |
| SCHEMBL15081643 | 0.90 | CTSC (0.46) | CTSCCTSKGPR119 | |
| SCHEMBL15081638 | 0.89 | CTSC (0.58) | CTSCCTSKKCNH2 | |
| SCHEMBL16065011 | 0.88 | CTSC (0.62) | CTSCCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758398-B1 | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL]-2-AZABICYCLO [2.2.1]HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |
| US-8999975-B2 | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| WO-2013041497-A1 | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL] -2-AZABICYCLO [2.2.1] HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-28 | — | — | WO | disclosed |