Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.37 |
| ▸ | DLK1 | P80370 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25926176 | 0.85 | RET (0.40) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL26204680 | 0.79 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1MAPTPDPK1CYP1A2 | |
| SCHEMBL25898919 | 0.77 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL12258192 | 0.75 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1MAPTMETAP2IDO1 | |
| SCHEMBL9605473 | 0.74 | CHEK1 (0.34) | PDPK1CHEK1AURKA | |
| SCHEMBL30515856 | 0.73 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL30515967 | 0.73 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL21579421 | 0.73 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL21579418 | 0.73 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL20176891 | 0.73 | KDM4E (0.45) | RETPI4KAXDHLRRK2PI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| EP-2252293-B1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC (US) | 2018-06-27 | — | — | EP | disclosed |
| US-8637542-B2 | Kinase inhibitors and methods of use | INTELLIKINE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| WO-2013139882-A1 | PYRAZOLOPYRIDINES FOR TREATMENT OF PARKINSONS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-09-26 | — | — | WO | disclosed |
| US-20110077268-A1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077268-A1 | KINASE INHIBITORS AND METHODS OF USE | MAP3K20, MAP3K1, PDPK1 | RET 443/4885PI4KA 44/4885XDH 3809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.