Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12562686 | 0.94 | PTK2 (0.55) | LRRK2PTK2 | |
| SCHEMBL1941927 | 0.90 | PTK2 (0.50) | LRRK2PTK2 | |
| SCHEMBL1941930 | 0.90 | PTK2 (0.50) | LRRK2PTK2 | |
| SCHEMBL14806703 | 0.89 | PTK2 (0.58) | LRRK2PTK2 | |
| SCHEMBL14823163 | 0.89 | LRRK2 (0.49) | LRRK2PTK2 | |
| SCHEMBL12562710 | 0.89 | PTK2 (0.58) | LRRK2PTK2 | |
| SCHEMBL1943773 | 0.88 | LRRK2 (0.66) | LRRK2PTK2 | |
| SCHEMBL14823165 | 0.88 | PTK2 (0.55) | LRRK2PTK2 | |
| SCHEMBL1943769 | 0.88 | LRRK2 (0.66) | LRRK2PTK2 | |
| SCHEMBL12563022 | 0.88 | LRRK2 (0.69) | LRRK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435411-B1 | 2,4-DIAMINOPYRIMIDINES FOR THE TREATMENT OF DISEASES CHARACTERISED BY EXCESSIVE OR ABNORMAL CELL PROLIFERATION | BOEHRINGER INGELHEIM INT (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-8410126-B2 | Pyrimidine inhibitors of PKTK2 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-04-02 | — | — | US | disclosed |