Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.66 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.66 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.60 |
| ▸ | CASP7 | P55210 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494141 | 0.82 | CDC25A (0.55) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL7946989 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL190520 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL13811793 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL25023044 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL25023120 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL18575999 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL25021694 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL13916483 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA | |
| Ursocholanic Acid SCHEMBL22871921 | 0.80 | GPBAR1 (1.00) | GPBAR1EPHA2HSD17B10TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410083-B2 | 23-substituted bile acids as TGR5 modulators and methods of use thereof | INTERCEPT PHARMACEUTICALS, INC. (US) | 2013-04-02 | — | — | US | disclosed |