Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 4/20 | 0.60 |
| ▸ | PAK4 | O96013 | 3/20 | 0.60 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.55 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.55 |
| ▸ | PAK3 | O75914 | 3/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | STK4 | Q13043 | 2/20 | 0.45 |
| ▸ | STK3 | Q13188 | 2/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.45 |
| ▸ | STK26 | Q9P289 | 2/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553476 | 0.89 | PKN1 (0.64) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL14824738 | 0.87 | PKN1 (0.52) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL13554122 | 0.86 | PKN1 (0.68) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035981 | 0.85 | PKN1 (0.59) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15030210 | 0.85 | PKN1 (0.59) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL12807687 | 0.84 | PKN1 (0.64) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL14824803 | 0.84 | PKN1 (0.66) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL13554109 | 0.83 | PKN1 (0.63) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035223 | 0.83 | PKN1 (0.65) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035199 | 0.83 | PKN1 (0.65) | PKN1PAK4PAK1PAK2PAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013043232-A2 | 8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER | AFRAXIS, INC. (US) | 2013-03-28 | — | — | WO | disclosed |