Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 4/20 | 0.65 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.65 |
| ▸ | PAK4 | O96013 | 2/20 | 0.65 |
| ▸ | PAK3 | O75914 | 2/20 | 0.62 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.62 |
| ▸ | WEE1 | P30291 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 6/20 | 0.56 |
| ▸ | CCND1 | P24385 | 6/20 | 0.56 |
| ▸ | CCND2 | P30279 | 6/20 | 0.56 |
| ▸ | CCND3 | P30281 | 6/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15030332 | 0.94 | PAK1 (0.73) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030435 | 0.87 | PAK1 (0.72) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL14824679 | 0.86 | PAK1 (0.62) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030449 | 0.83 | PKN1 (0.70) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030453 | 0.82 | PAK1 (0.79) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13553581 | 0.82 | PAK1 (0.72) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13554057 | 0.81 | PAK1 (0.76) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13553595 | 0.81 | PAK1 (0.81) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13553596 | 0.80 | PAK1 (0.78) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL12807725 | 0.80 | PAK1 (0.80) | PAK1PKN1PAK4PAK3PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013043232-A2 | 8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER | AFRAXIS, INC. (US) | 2013-03-28 | — | — | WO | disclosed |