Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737566 | 0.87 | HTR2C (0.55) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL224324 | 0.87 | HTR2C (0.55) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL2531236 | 0.84 | HTR2C (0.62) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL4979009 | 0.84 | HTR2C (0.62) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL226198 | 0.83 | HTR2C (0.53) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL224325 | 0.83 | HTR2C (0.60) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL27737538 | 0.83 | HTR2C (0.60) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL3651360 | 0.83 | HTR2C (0.60) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL224996 | 0.83 | HTR2C (0.63) | HTR2CHTR2AHTR7HTR6KDM4E | |
| SCHEMBL224995 | 0.83 | HTR2C (0.63) | HTR2CHTR2AHTR7HTR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415350-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2013-04-09 | — | — | US | disclosed |