Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 5/20 | 0.35 |
| ▸ | DCPS | Q96C86 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483043 | 0.89 | NR1H4 (0.37) | CYP11B1CYP11B2NPSR1SLC6A9GLP1R | |
| SCHEMBL1482217 | 0.88 | NR1H4 (0.38) | CYP11B1CYP11B2SLC6A9GLP1RCYP2D6 | |
| SCHEMBL1482427 | 0.87 | NR1H4 (0.36) | CYP11B1CYP11B2NPSR1PDE10ASLC6A9 | |
| SCHEMBL1483027 | 0.86 | PDE10A (0.39) | PDE10AGLP1RHTR1ACYP2C8KCNH2 | |
| SCHEMBL1482864 | 0.85 | CYP11B1 (0.36) | CYP11B1CYP11B2NPSR1PDE10ASLC6A9 | |
| SCHEMBL1482832 | 0.85 | KDM4E (0.52) | CYP11B1CYP11B2KDM4ELMNAHTT | |
| SCHEMBL1482742 | 0.83 | NPSR1 (0.43) | KDM4ELMNAHTTNPSR1CYP2D6 | |
| SCHEMBL1482365 | 0.82 | GLP1R (0.37) | CYP11B1CYP11B2PDE10AGLP1RKDM1A | |
| SCHEMBL1482785 | 0.81 | KCNN4 (0.38) | KCNN4CYP11B1CYP11B2KDM4ELMNA | |
| SCHEMBL1482770 | 0.80 | KCNH2 (0.41) | CYP11B1CYP11B2KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309581-B2 | Benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110077273-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077273-A1 | NEW BENZIMIDAZOLE DERIVATIVES | BRI3BP, CYP3A4, RB1 | KCNN4 1390/4885CYP11B1 190/4885CYP11B2 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.