Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27265753 | 0.88 | SMN1; SMN2 (0.45) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| Bromide SCHEMBL9937840 | 0.86 | SMN1; SMN2 (0.44) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| SCHEMBL5155 | 0.83 | — | — | |
| SCHEMBL29419394 | 0.83 | — | — | |
| SCHEMBL24916774 | 0.83 | CCR1 (0.52) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| SCHEMBL30201993 | 0.83 | CCR1 (0.52) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| SCHEMBL681574 | 0.82 | KCNH2 (0.64) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| Bromide SCHEMBL11282133 | 0.81 | CCR1 (0.46) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| SCHEMBL10144469 | 0.81 | KCNH2 (0.54) | KCNH2SMN1; SMN2CCR1CCR8NOS2 | |
| SCHEMBL10416918 | 0.80 | KCNH2 (0.38) | KCNH2SMN1; SMN2CCR1CCR8HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576510-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153509-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-08 | — | — | WO | disclosed |