Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108801 | 0.88 | CYP1A2 (0.72) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL22335924 | 0.86 | CYP1A2 (0.64) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL9498762 | 0.86 | CYP1A2 (0.64) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL9993619 | 0.85 | CYP1A2 (0.72) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL22070741 | 0.84 | CYP1A2 (0.62) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL31185994 | 0.84 | CYP1A2 (0.70) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL28034344 | 0.82 | CYP1A2 (0.68) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL7336055 | 0.82 | CYP1A2 (0.77) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL31186195 | 0.81 | CYP1A2 (0.66) | CYP1A2MAPTGAACA12CA1 | |
| SCHEMBL536661 | 0.80 | CYP1A2 (0.74) | CYP1A2MAPTGAACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576510-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153509-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-08 | — | — | WO | disclosed |