Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.40 |
| ▸ | PIM1 | P11309 | 10/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905659 | 0.88 | PIM2 (0.47) | PIM2PIM3PIM1 | |
| SCHEMBL2525454 | 0.84 | PIM2 (0.46) | PIM2PIM3PIM1 | |
| SCHEMBL2521998 | 0.84 | PIM2 (0.46) | PIM2PIM3PIM1LRRK2 | |
| SCHEMBL14838538 | 0.84 | PIM2 (0.46) | PIM2PIM3PIM1LRRK2 | |
| SCHEMBL14838485 | 0.84 | SMPD3 (0.40) | PIM2PIM3PIM1LRRK2 | |
| SCHEMBL14838534 | 0.81 | MAP4K4 (0.39) | PIM2PIM3PIM1 | |
| SCHEMBL14838516 | 0.81 | LRRK2 (0.36) | PIM2PIM3PIM1LRRK2 | |
| SCHEMBL14800848 | 0.80 | PIM1 (0.48) | PIM2PIM3PIM1 | |
| SCHEMBL14838350 | 0.80 | PIM1 (0.35) | PIM2PIM3PIM1 | |
| SCHEMBL14838568 | 0.78 | PIK3CA (0.39) | PIM2PIM3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013045461-A1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |