Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16253472 | 0.92 | SYK (0.72) | SYKKCNH2 | |
| SCHEMBL14838990 | 0.87 | SYK (0.88) | SYKAURKBKDRMAPK3MAPK1 | |
| SCHEMBL14838892 | 0.85 | SYK (0.76) | SYKKCNH2 | |
| SCHEMBL16253407 | 0.85 | SYK (0.66) | SYKAURKBKDRJAK2LCK | |
| SCHEMBL16253475 | 0.83 | SYK (0.74) | SYKAURKBKDR | |
| SCHEMBL16253411 | 0.83 | SYK (0.80) | SYKAURKBKDR | |
| SCHEMBL16253408 | 0.83 | SYK (1.00) | SYKAURKBKDRJAK2LCK | |
| SCHEMBL15935586 | 0.83 | SYK (0.81) | SYKAURKBKDR | |
| SCHEMBL16743268 | 0.81 | SYK (0.74) | SYKAURKBKDRJAK2LCK | |
| SCHEMBL15935611 | 0.81 | SYK (0.64) | SYKAURKBKDRJAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013047813-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | 大鵬薬品工業株式会社 (JP) | 2013-04-04 | — | — | WO | disclosed |