Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL18485329 | 1.00 | PRMT5 (0.38) | PRMT5WDR77CTSSSMN1; SMN2PKM | |
| SCHEMBL2894546 | 0.95 | PRMT5 (0.40) | PRMT5WDR77CTSSSMN1; SMN2PKM | |
| SCHEMBL3854537 | 0.95 | PRMT5 (0.40) | PRMT5WDR77CTSSSMN1; SMN2PKM | |
| SCHEMBL14839721 | 0.82 | PRMT5 (0.37) | PRMT5WDR77CTSSSMN1; SMN2PKM | |
| SCHEMBL3492252 | 0.82 | POLB (0.45) | PRMT5WDR77SMN1; SMN2PKMPOLB | |
| SCHEMBL3493429 | 0.81 | MAPK1 (0.43) | PRMT5WDR77SMN1; SMN2PKMPOLB | |
| SCHEMBL1422722 | 0.80 | RECQL (0.56) | PRMT5WDR77SMN1; SMN2PKMPOLB | |
| SCHEMBL3493285 | 0.78 | POLB (0.44) | PRMT5WDR77SMN1; SMN2PKMPOLB | |
| SCHEMBL29188207 | 0.77 | POLB (0.36) | POLBALDH1A1LMNAKMT2ACYP1A2 | |
| SCHEMBL2900509 | 0.77 | POLB (0.36) | POLBALDH1A1LMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018374-B2 | Crystal of amide compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-04-28 | — | — | US | disclosed |
| EP-2583967-B1 | CRYSTAL OF AMIDE COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2014-10-01 | — | — | EP | disclosed |
| US-20130252954-A2 | CRYSTAL OF AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-09-26 | — | — | US | disclosed |
| EP-2583967-A1 | CRYSTAL OF AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2013-04-24 | — | — | EP | disclosed |
| US-20130090337-A1 | CRYSTAL OF AMIDE COMPOUND | KITAYAMA MASATO (JP) | 2013-04-11 | — | — | US | disclosed |