Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.43 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.43 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.43 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.43 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.43 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.43 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.43 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | LDHB | P07195 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495137 | 1.00 | JAK2 (0.55) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL2640308 | 1.00 | JAK2 (0.55) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL16495242 | 0.90 | JAK2 (0.47) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL12069142 | 0.87 | JAK2 (0.46) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL12067750 | 0.87 | JAK2 (0.52) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL12067767 | 0.86 | JAK3 (0.53) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL1693860 | 0.86 | JAK3 (0.53) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL16494538 | 0.86 | JAK3 (0.53) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL2035333 | 0.85 | JAK2 (0.46) | JAK2JAK3JAK1PIK3CDPIK3R1 | |
| SCHEMBL2035331 | 0.85 | JAK2 (0.46) | JAK2JAK3JAK1PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130089512-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2013-04-11 | — | — | US | disclosed |
| US-20130089512-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2013-04-11 | — | — | US | disclosed |
| US-20130089512-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2013-04-11 | — | — | US | disclosed |
| EP-2397482-A1 | Heteroaryl imidazolone derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-12-21 | — | — | EP | disclosed |
| EP-2397482-A1 | Heteroaryl imidazolone derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-12-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130089512-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.