Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 9/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842076 | 0.92 | FASN (0.65) | FASNCHRM1CHRNA7KDM1AGSK3B | |
| SCHEMBL14842333 | 0.91 | FASN (0.60) | FASNCHRM1CHRNA7KDM1AGSK3B | |
| SCHEMBL15543586 | 0.90 | FASN (0.63) | FASNCHRM1CHRNA7KDM1AGSK3B | |
| SCHEMBL14842029 | 0.90 | FASN (0.60) | FASNCHRM1CHRNA7KDM1AGSK3B | |
| SCHEMBL15582386 | 0.88 | FASN (0.72) | FASNCHRNA7GSK3BOPRM1SIGMAR1 | |
| SCHEMBL15543303 | 0.87 | FASN (0.52) | FASNCHRM1CHRNA7KDM1AGSK3B | |
| SCHEMBL15544417 | 0.87 | FASN (0.48) | FASNOPRM1SIGMAR1 | |
| SCHEMBL15543895 | 0.87 | FASN (0.49) | FASNCHRM1OPRM1SIGMAR1 | |
| SCHEMBL14720426 | 0.87 | FASN (0.64) | FASNCHRNA7OPRM1SIGMAR1 | |
| SCHEMBL15543614 | 0.87 | FASN (0.65) | FASNCHRNA7KDM1AGSK3BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | claimed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2013052716-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-04-11 | — | — | WO | disclosed |