Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.38 |
| ▸ | CA2 | P00918 | 7/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737343 | 0.81 | KMT2A (0.39) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL29880067 | 0.81 | KMT2A (0.39) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL19013571 | 0.78 | KDM4E (0.40) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL18989655 | 0.78 | KDM4E (0.40) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL20592220 | 0.78 | KDM4E (0.40) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL22503762 | 0.78 | KMT2A (0.43) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL20442243 | 0.78 | KMT2A (0.43) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL20424215 | 0.78 | KMT2A (0.43) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL20398734 | 0.78 | KMT2A (0.43) | CA1CA2CA9CA12KMT2A | |
| SCHEMBL30123091 | 0.78 | KMT2A (0.43) | CA1CA2CA9CA12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763533-B1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-12-29 | — | — | EP | disclosed |
| EP-2919782-B1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-2919782-B1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-26 | — | — | EP | disclosed |
| US-9428492-B2 | Secondary alcohol substituted triazoles as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-9428492-B2 | Secondary alcohol substituted triazoles as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-9428492-B2 | Secondary alcohol substituted triazoles as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200001-B2 | Triazolyl PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-08 | — | — | US | disclosed |
| EP-2919782-A1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
| EP-2763533-A1 | TRIAZOLYL PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2014078220-A1 | SECONDARY ALCOHOL SUBSITUTED TRIAZOLES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2013052526-A1 | TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249134-A1 | TRIAZOLYL PDE10 INHIBITORS | PDE10A, PDE12, PDE4A | CA1 3306/4885CA2 3428/4885CA9 2386/4885 |
| US-20150284368-A1 | SECONDARY ALCOHOL SUBSTITUTED TRIAZOLES AS PDE10 INHIBITORS | PDE10A, PDE3A, PDE4B | CA1 3220/4885CA2 4469/4885CA9 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.