SCHEMBL14844019

SCHEMBL14844019

O=C(c1ccccc1-n1cccn1)N1CC2CC(C1)CN(c1cnc3cc(Cl)ccc3n1)C2

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 20/20 0.68
HCRTR1 O43613 19/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14843833 0.97 HCRTR2 (0.68) HCRTR2HCRTR1
SCHEMBL14843660 0.91 HCRTR2 (0.67) HCRTR2HCRTR1
SCHEMBL14844250 0.90 HCRTR2 (0.82) HCRTR2HCRTR1
SCHEMBL14843741 0.90 HCRTR2 (0.68) HCRTR2HCRTR1
SCHEMBL14843945 0.82 HCRTR2 (0.66) HCRTR2HCRTR1
SCHEMBL14844136 0.81 HCRTR1 (0.66) HCRTR2HCRTR1
SCHEMBL14844103 0.81 HCRTR2 (0.56) HCRTR2HCRTR1
SCHEMBL1672089 0.81 HCRTR2 (1.00) HCRTR2HCRTR1
SCHEMBL14843665 0.80 HCRTR2 (0.55) HCRTR2HCRTR1
SCHEMBL14844268 0.78 HCRTR2 (0.57) HCRTR2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 WO claimed
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 WO disclosed