SCHEMBL14844166

SCHEMBL14844166

O=C(c1ccccc1-c1ccccc1)N1CC2CN(c3cnc4ccccc4n3)CC(C1)O2

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 20/20 0.79
HCRTR2 O43614 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14844272 0.90 HCRTR1 (0.65) HCRTR1HCRTR2
SCHEMBL14843576 0.90 HCRTR2 (0.65) HCRTR1HCRTR2
SCHEMBL14844204 0.90 HCRTR1 (0.65) HCRTR1HCRTR2
SCHEMBL14844052 0.89 HCRTR1 (0.63) HCRTR1HCRTR2
SCHEMBL14844059 0.88 HCRTR1 (0.64) HCRTR1HCRTR2
SCHEMBL1672268 0.88 HCRTR1 (1.00) HCRTR1HCRTR2
SCHEMBL14844399 0.88 HCRTR2 (0.61) HCRTR1HCRTR2
SCHEMBL14844073 0.86 HCRTR1 (0.80) HCRTR1HCRTR2
SCHEMBL14844086 0.82 HCRTR2 (0.55) HCRTR1HCRTR2
SCHEMBL1671269 0.80 HCRTR1 (1.00) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 WO disclosed