SCHEMBL14844232

SCHEMBL14844232

Cc1ccc(-n2nccn2)c(C(=O)N2CC3CC(C2)CN(c2ncc(Br)cn2)C3)c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 20/20 0.60
HCRTR1 O43613 18/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14843639 0.89 HCRTR2 (0.58) HCRTR2HCRTR1
SCHEMBL14843926 0.84 HCRTR2 (0.80) HCRTR2HCRTR1
SCHEMBL14844063 0.82 HCRTR2 (0.61) HCRTR2HCRTR1
SCHEMBL14844206 0.79 HCRTR2 (0.65) HCRTR2HCRTR1
SCHEMBL14850874 0.79 HCRTR2 (0.60) HCRTR2HCRTR1
Hydrochloric Acid SCHEMBL14843973 0.78 HCRTR2 (0.59) HCRTR2HCRTR1
SCHEMBL14843881 0.77 HCRTR2 (0.55) HCRTR2HCRTR1
SCHEMBL14844159 0.77 HCRTR2 (0.57) HCRTR2HCRTR1
SCHEMBL14844341 0.77 HCRTR1 (0.61) HCRTR2HCRTR1
SCHEMBL14844170 0.77 HCRTR2 (0.57) HCRTR2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 WO disclosed