Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842767 | 0.88 | MEN1 (0.55) | MEN1KMT2ATRPM8ALDH1A1PSEN1 | |
| SCHEMBL14845326 | 0.83 | PSEN1 (0.43) | MEN1KMT2ATRPM8ALDH1A1PSEN1 | |
| SCHEMBL15969576 | 0.79 | PSEN1 (0.44) | MEN1KMT2ATRPM8PSEN1PSEN2 | |
| SCHEMBL14854046 | 0.79 | PSEN1 (0.44) | MEN1KMT2ATRPM8PSEN1PSEN2 | |
| SCHEMBL14842546 | 0.77 | MEN1 (0.61) | MEN1KMT2ATRPM8PSEN1PSEN2 | |
| SCHEMBL15981222 | 0.74 | MEN1 (0.56) | MEN1KMT2ATRPM8ALDH1A1PSEN1 | |
| SCHEMBL14842820 | 0.72 | PSEN1 (0.53) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL14853968 | 0.69 | MEN1 (0.50) | MEN1KMT2ATRPM8ALDH1A1PSEN1 | |
| SCHEMBL14842530 | 0.69 | MEN1 (0.53) | MEN1KMT2ATRPM8ALDH1A1PSEN1 | |
| SCHEMBL2567557 | 0.68 | MAPT (0.48) | MEN1KMT2AALDH1A1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013052700-A1 | NOVEL SULFONAMIDES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-04-11 | — | — | WO | disclosed |