Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10142784 | 1.00 | TMPRSS2 (0.31) | TMPRSS2RIPK1 | |
| SCHEMBL10142785 | 0.95 | TMPRSS2 (0.31) | TMPRSS2RIPK1 | |
| SCHEMBL19650099 | 0.94 | TMPRSS2 (0.31) | TMPRSS2RIPK1 | |
| SCHEMBL10142368 | 0.93 | TMPRSS2 (0.31) | TMPRSS2RIPK1 | |
| SCHEMBL10142355 | 0.91 | — | — | |
| SCHEMBL10142778 | 0.91 | TMPRSS2 (0.34) | TMPRSS2 | |
| SCHEMBL10142790 | 0.91 | TMPRSS2 (0.30) | TMPRSS2 | |
| Gs-6620 SCHEMBL14845666 | 0.90 | CYP3A4 (0.41) | RIPK1 | |
| Gs-6620 SCHEMBL18293556 | 0.90 | CYP3A4 (0.41) | RIPK1 | |
| Gs-6620 SCHEMBL10142646 | 0.90 | CYP3A4 (0.41) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576534-B1 | 1'-SUBSTITUTED-CARBA-NUCLEOSIDE PRODRUGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2014-03-19 | — | — | EP | disclosed |
| US-8415308-B2 | 1′-substituted-carba-nucleoside prodrugs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2013-04-09 | — | — | US | disclosed |