Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.43 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14850557 | 0.91 | PIK3CD (0.42) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL14850560 | 0.90 | PIK3CG (0.42) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL24688296 | 0.78 | PIK3CD (0.42) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL681832 | 0.78 | PIK3CG (0.56) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15960533 | 0.77 | PIK3CD (0.36) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL14850562 | 0.77 | PIK3CG (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15597618 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15597551 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL15960534 | 0.75 | MAPK14 (0.36) | PIK3CDPIK3CGOPRM1TACR3 | |
| SCHEMBL4173430 | 0.75 | PIK3CG (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC | 2014-08-21 | — | — | US | disclosed |
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC | 2014-08-21 | — | — | US | disclosed |
| WO-2013052699-A2 | NOVEL QUINOXALINE INHIBITORS OF PI3K | GILEAD CALISTOGA LLC (US) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235643-A1 | NOVEL QUINOXALINE INHIBITORS OF PI3K | PIK3R5, PIK3CA, PIK3CD | PIK3CD 3/4885PIK3CG 6/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.