Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | G6PD | P11413 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917098 | 1.00 | MAPT (0.41) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL8916837 | 1.00 | MAPT (0.41) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL12436835 | 0.90 | EPHX2 (0.42) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL890177 | 0.90 | EPHX2 (0.42) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL890157 | 0.90 | EPHX2 (0.42) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL22722033 | 0.85 | MAPT (0.41) | MAPTBTKTSHRG6PDALDH1A1 | |
| SCHEMBL12437109 | 0.85 | MAPT (0.41) | MAPTBTKTSHRG6PDALDH1A1 | |
| SCHEMBL18526462 | 0.84 | BTK (0.56) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL756367 | 0.84 | BTK (0.56) | MAPTBTKEPHX2JAK1TSHR | |
| SCHEMBL754127 | 0.84 | BTK (0.56) | MAPTBTKEPHX2JAK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400846-B1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARM INC (US) | 2016-10-05 | — | — | EP | disclosed |
| WO-2013052369-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2013-04-11 | — | — | WO | disclosed |