Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856711 | 0.88 | HDAC3 (0.36) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL15233019 | 0.88 | HDAC1 (0.41) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL14189703 | 0.81 | HDAC3 (0.45) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL16639002 | 0.80 | TAAR1 (0.45) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL24437513 | 0.78 | HRH3 (0.56) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL17469523 | 0.78 | HDAC3 (0.43) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL17804399 | 0.76 | HDAC3 (0.44) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL15590854 | 0.74 | HDAC3 (0.41) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL15590852 | 0.74 | HDAC3 (0.41) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL17080226 | 0.74 | ATM (0.41) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696907-B1 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2013-04-17 | — | — | EP | claimed |
| CN-1889949-B | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND | 2010-06-16 | — | — | CN | claimed |
| CN-1889949-A | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND (US) | 2007-01-03 | — | — | CN | claimed |
| CN-1889949-B | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND | 2010-06-16 | — | — | CN | disclosed |
| CN-1889949-A | PDK-1/Akt signaling inhibitors | UNIV OHIO STATE RES FOUND (US) | 2007-01-03 | — | — | CN | disclosed |