Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856477 | 1.00 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1HSP90B1HCRTR1HCRTR2 | |
| SCHEMBL14856704 | 1.00 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1HSP90B1HCRTR1HCRTR2 | |
| SCHEMBL14856603 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14990840 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14856610 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14856608 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14856604 | 0.87 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL14856345 | 0.82 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1HSP90B1HDAC8 | |
| SCHEMBL14856002 | 0.82 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1HSP90B1HDAC8 | |
| SCHEMBL14991119 | 0.81 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSP90B1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580193-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS HSP90 INHIBTORS | Chroma Therapeutics Ltd. (GB) | 2013-04-17 | — | — | EP | claimed |
| WO-2011154708-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS HSP90 INHIBTORS | CHROMA THERAPEUTICS LTD (GB) | 2011-12-15 | — | — | WO | claimed |