Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | FABP2 | P12104 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370676 | 0.86 | PTGDR2 (0.75) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14859000 | 0.85 | PTGDR2 (0.63) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14860438 | 0.84 | PTGDR2 (0.57) | PTGDR2SMN1; SMN2PPARAALDH1A1FABP2 | |
| SCHEMBL14871008 | 0.83 | PTGDR2 (0.61) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1368383 | 0.83 | PTGDR2 (0.63) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1368120 | 0.83 | PTGDR2 (0.63) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1369200 | 0.82 | PTGDR2 (0.57) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1369034 | 0.80 | PTGDR2 (0.52) | PTGDR2SMN1; SMN2PPARAALDH1A1FABP2 | |
| SCHEMBL1366799 | 0.80 | PTGDR2 (0.66) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1369213 | 0.79 | PTGDR2 (0.53) | PTGDR2SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586772-A1 | ISOQUINOLINE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2013-05-01 | — | — | EP | disclosed |
| US-20130096310-A1 | ISOQUINOLINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-04-18 | — | — | US | disclosed |
| US-20130096310-A1 | ISOQUINOLINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096310-A1 | ISOQUINOLINE DERIVATIVE | NR1H2, NR3C2, HRH1 | PTGDR2 219/4885SMN1; SMN2 3369/4885PPARA 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.