Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 16/20 | 1.00 |
| ▸ | PNP | P00491 | 2/20 | 0.72 |
| ▸ | MYC | P01106 | 1/20 | 0.65 |
| ▸ | MAX | P61244 | 1/20 | 0.65 |
| ▸ | TDP2 | O95551 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860886 | 1.00 | TDP1 (1.00) | TDP1PNPMYCMAXTDP2 | |
| SCHEMBL14860885 | 1.00 | TDP1 (1.00) | TDP1PNPMYCMAXTDP2 | |
| SCHEMBL27274998 | 0.87 | TDP1 (0.77) | TDP1PNPTDP2MEN1ALDH1A1 | |
| SCHEMBL30841583 | 0.87 | TDP1 (0.77) | TDP1PNPTDP2MEN1ALDH1A1 | |
| SCHEMBL1249438 | 0.86 | TDP1 (0.75) | TDP1MYCMAXHPGDCISD1 | |
| SCHEMBL1249440 | 0.86 | TDP1 (0.75) | TDP1MYCMAXHPGDCISD1 | |
| SCHEMBL12218285 | 0.86 | TDP1 (0.75) | TDP1MYCMAXHPGDCISD1 | |
| SCHEMBL14860905 | 0.84 | TDP1 (1.00) | TDP1PNPTDP2MEN1ALDH1A1 | |
| SCHEMBL14860906 | 0.84 | TDP1 (1.00) | TDP1PNPTDP2MEN1ALDH1A1 | |
| SCHEMBL14860904 | 0.84 | TDP1 (1.00) | TDP1PNPTDP2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |