Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 16/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | NSD2 | O96028 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | GFER | P55789 | 1/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | TDP2 | O95551 | 1/20 | 0.68 |
| ▸ | PNP | P00491 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860934 | 1.00 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL14860937 | 1.00 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL14860975 | 0.88 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL14860977 | 0.88 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL14860979 | 0.88 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL3402662 | 0.86 | TDP1 (0.75) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL3402663 | 0.86 | TDP1 (0.75) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL15421305 | 0.85 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL15421307 | 0.85 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA | |
| SCHEMBL15421303 | 0.85 | TDP1 (1.00) | TDP1KDM4ENSD2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055771-A1 | THIOXOTHIAZOLIDINONE DERIVATIVES USEFUL AS INHIBITORS OF TDP1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-04-18 | — | — | WO | disclosed |