Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3783562 | 0.83 | KDM1A (0.35) | KDM1ASIGMAR1MAOBMAOA | |
| SCHEMBL14840033 | 0.81 | HDAC9 (0.34) | KDM1ASIGMAR1MAOBMAOA | |
| SCHEMBL27967814 | 0.76 | KDM1A (0.39) | KDM1ASIGMAR1MAOBMAOA | |
| SCHEMBL2146984 | 0.72 | KDM1A (0.42) | KDM1ASIGMAR1MAOB | |
| SCHEMBL29453777 | 0.72 | KDM1A (0.42) | KDM1ASIGMAR1MAOB | |
| SCHEMBL5960895 | 0.72 | KDM1A (0.42) | KDM1ASIGMAR1MAOB | |
| SCHEMBL302419 | 0.72 | KDM1A (0.42) | KDM1ASIGMAR1MAOB | |
| Hydrochloric Acid SCHEMBL27310401 | 0.71 | KDM1A (0.41) | KDM1ASIGMAR1MAOB | |
| Hydrochloric Acid SCHEMBL1970466 | 0.71 | KDM1A (0.41) | KDM1ASIGMAR1MAOB | |
| SCHEMBL301710 | 0.70 | MAOB (0.43) | KDM1ASIGMAR1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766004-A1 | R(+)-N-METHYL-PROPARGYL-AMINOINDAN | Teva Pharmaceuticals USA, Inc. (US) | 2014-08-20 | — | — | EP | claimed |
| CN-103930100-A | R(+)-n-methyl-propargyl-aminoindan | TEVA PHARMA | 2014-07-16 | — | — | CN | claimed |
| CN-103857389-A | Rasagiline citramide | TEVA PHARMA | 2014-06-11 | — | — | CN | claimed |
| WO-2013055689-A1 | R(+)-N-METHYL-PROPARGYL-AMINOINDAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2013-04-18 | — | — | WO | claimed |
| EP-2766004-A1 | R(+)-N-METHYL-PROPARGYL-AMINOINDAN | Teva Pharmaceuticals USA, Inc. (US) | 2014-08-20 | — | — | EP | disclosed |
| EP-2766007-A1 | RASAGILINE CITRAMIDE | Teva Pharmaceutical Industries Ltd. (IL) | 2014-08-20 | — | — | EP | disclosed |
| CN-103930100-A | R(+)-n-methyl-propargyl-aminoindan | TEVA PHARMA | 2014-07-16 | — | — | CN | disclosed |
| CN-103874487-A | R(+)-N-formyl-propargyl-aminoindan | TEVA PHARMA | 2014-06-18 | — | — | CN | disclosed |
| WO-2013055689-A1 | R(+)-N-METHYL-PROPARGYL-AMINOINDAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013055684-A1 | RASAGILINE CITRAMIDE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2013-04-18 | — | — | WO | disclosed |