Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342055 | 0.91 | KDM4E (0.34) | MAPTTSHRSMN1; SMN2RXFP1MAPK1 | |
| SCHEMBL4524475 | 0.91 | PDE4B (0.34) | LMNAMAPTTSHRSMN1; SMN2USP2 | |
| SCHEMBL4531869 | 0.86 | PDE4B (0.33) | MAPTHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL4017828 | 0.81 | TNKS (0.35) | LMNAKDM4EALDH1A1HPGDPDE4B | |
| SCHEMBL8212482 | 0.79 | POLB (0.36) | LMNAMAPTTSHRRXFP1MAPK1 | |
| SCHEMBL4525068 | 0.78 | TNKS (0.35) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4016542 | 0.78 | CYP19A1 (0.37) | LMNAMAPTHTTKMT2AKDM4E | |
| SCHEMBL4016694 | 0.78 | KDM4E (0.36) | LMNAKDM4EALDH1A1PDE4BCYP17A1 | |
| SCHEMBL4537205 | 0.78 | NPC1 (0.36) | MAPTTP53HTTMEN1KMT2A | |
| SCHEMBL4013156 | 0.78 | HRH4 (0.33) | LMNAKDM4EALDH1A1PDE4BCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074106-B1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LAB LTD (IN) | 2013-04-17 | — | — | EP | disclosed |