Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.32 |
| ▸ | RAF1 | P04049 | 7/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808146 | 0.94 | OPRL1 (0.38) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2805565 | 0.88 | OPRL1 (0.38) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2805695 | 0.88 | OPRL1 (0.37) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2807541 | 0.87 | DHODH (0.35) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2810028 | 0.87 | CNR2 (0.40) | PDE2A | |
| SCHEMBL2805193 | 0.86 | HDAC3 (0.38) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2809544 | 0.84 | OPRL1 (0.39) | OPRL1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2809999 | 0.84 | BDKRB1 (0.36) | OPRL1RAF1BRAFPDE2A | |
| SCHEMBL185964 | 0.84 | BDKRB1 (0.36) | OPRL1RAF1BRAFPDE2A | |
| SCHEMBL185516 | 0.83 | OPRL1 (0.36) | OPRL1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |