Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1480103 | 0.95 | TSHR (0.40) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL2151668 | 0.93 | CYP3A4 (0.41) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL13500592 | 0.93 | CYP3A4 (0.41) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL598045 | 0.91 | — | — | |
| SCHEMBL14865424 | 0.84 | TSHR (0.39) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL17207907 | 0.82 | CYP3A4 (0.35) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL25247568 | 0.81 | TSHR (0.38) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL14173382 | 0.81 | TP53 (0.40) | TSHRTP53HSD17B10MGAMGAA | |
| SCHEMBL8252653 | 0.78 | TSHR (0.48) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL18952233 | 0.77 | TP53 (0.36) | TSHRTP53HSD17B10MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806342-B1 | 3-CARBAMOYL-2-PYRIDONE DERIVATIVE | SHIONOGI & CO (JP) | 2013-04-17 | — | — | EP | disclosed |