Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.42 |
| ▸ | CNR2 | P34972 | 6/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19418459 | 1.00 | EPHX2 (0.42) | EPHX2CNR2CNR1MAPK10MAPK8 | |
| SCHEMBL19418448 | 0.91 | MAPK10 (0.45) | EPHX2CNR2MAPK10MAPK8MAPK14 | |
| SCHEMBL13159815 | 0.91 | MAPK10 (0.45) | EPHX2CNR2MAPK10MAPK8MAPK14 | |
| SCHEMBL13159675 | 0.88 | EPHX2 (0.44) | EPHX2MAPK10MAPK8MAPK14 | |
| SCHEMBL19418574 | 0.88 | EPHX2 (0.44) | EPHX2MAPK10MAPK8MAPK14 | |
| SCHEMBL19418578 | 0.87 | CNR2 (0.42) | EPHX2CNR2CNR1MAPK10MAPK8 | |
| SCHEMBL13159679 | 0.87 | CNR2 (0.42) | EPHX2CNR2CNR1MAPK10MAPK8 | |
| SCHEMBL13160140 | 0.85 | CNR2 (0.42) | EPHX2CNR2CNR1MAPK10MAPK8 | |
| SCHEMBL13159816 | 0.83 | CNR2 (0.43) | EPHX2CNR2CNR1MAPK10MAPK8 | |
| SCHEMBL13159682 | 0.82 | EPHX2 (0.43) | EPHX2MAPK10MAPK8MAPK14P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539323-B3 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2017-10-04 | — | — | EP | disclosed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |