Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 5/20 | 0.52 |
| ▸ | ATR | Q13535 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865735 | 0.95 | PRKD1 (0.48) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865823 | 0.95 | PRKD1 (0.48) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865636 | 0.95 | PRKD1 (0.46) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865613 | 0.92 | PRKD1 (0.43) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865718 | 0.91 | PRKD1 (0.43) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL12987696 | 0.88 | ATR (0.66) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865627 | 0.87 | ATR (0.45) | PRKD1ATRATMCYP1A2CYP3A4 | |
| SCHEMBL14865742 | 0.86 | PRKD1 (0.41) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865769 | 0.85 | PRKD1 (0.48) | PRKD1ATRATMPRKD3PRKD2 | |
| SCHEMBL14865787 | 0.85 | PRKD1 (0.51) | PRKD1ATRATMPRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877759-B2 | Aminopyrazines as ATR kinase inhibitors | Vertex Pharnaceuticals Incorporated (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130095193-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130095193-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, CHEK2 | PRKD1 89/4885ATR 1/4885ATM 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.