Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987496 | 0.92 | BRAF (0.66) | BRAF | |
| SCHEMBL9987495 | 0.92 | BRAF (0.66) | BRAF | |
| SCHEMBL14865884 | 0.92 | BRAF (0.72) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL16266456 | 0.90 | BRAF (0.61) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL12669636 | 0.89 | BRAF (0.58) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL12669230 | 0.89 | BRAF (0.58) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL24257038 | 0.89 | BRAF (0.68) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL16266520 | 0.88 | BRAF (0.74) | BRAFHDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL12072967 | 0.88 | BRAF (0.75) | BRAF | |
| SCHEMBL16266525 | 0.87 | BRAF (0.70) | BRAFHDAC3HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096149-A1 | HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-04-18 | — | — | US | disclosed |
| US-20130096149-A1 | HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096149-A1 | HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | BRAF, RAF1, ARAF | BRAF 1/4885HDAC3 1149/4885HDAC1 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.