Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.73 |
| ▸ | ROS1 | P08922 | 6/20 | 0.67 |
| ▸ | GAK | O14976 | 3/20 | 0.67 |
| ▸ | INSR | P06213 | 3/20 | 0.67 |
| ▸ | IGF1R | P08069 | 3/20 | 0.67 |
| ▸ | LTK | P29376 | 3/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.67 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.67 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.67 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.67 |
| ▸ | FES | P07332 | 3/20 | 0.67 |
| ▸ | FLT3 | P36888 | 3/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.67 |
| ▸ | PLK4 | O00444 | 2/20 | 0.67 |
| ▸ | ERN1 | O75460 | 2/20 | 0.67 |
| ▸ | STK10 | O94804 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 2/20 | 0.67 |
| ▸ | FYN | P06241 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14866451 | 0.92 | ALK (0.72) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866574 | 0.92 | ALK (0.72) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866288 | 0.91 | ALK (0.71) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866454 | 0.91 | ALK (0.71) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866572 | 0.91 | ALK (0.71) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866294 | 0.91 | ALK (0.71) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL3309148 | 0.90 | ALK (0.77) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866305 | 0.90 | ALK (0.70) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866302 | 0.90 | ALK (0.70) | ALKROS1GAKINSRIGF1R | |
| SCHEMBL14866389 | 0.90 | ALK (0.76) | ALKROS1GAKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ERBB4, EGFR, ALK | ALK 3/4885ROS1 46/4885GAK 1183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.