Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.89 |
| ▸ | TTK | P33981 | 4/20 | 0.79 |
| ▸ | FES | P07332 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.62 |
| ▸ | ULK1 | O75385 | 2/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | CASK | O14936 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14866318 | 0.94 | ALK (1.00) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866148 | 0.91 | ALK (0.77) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866260 | 0.91 | ALK (0.76) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866499 | 0.91 | ALK (0.76) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866256 | 0.90 | ALK (0.76) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866157 | 0.90 | ALK (0.75) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866359 | 0.90 | TTK (0.81) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866525 | 0.89 | ALK (0.89) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL14866145 | 0.89 | ALK (0.79) | ALKTTKFESFLT3ZAP70 | |
| SCHEMBL17731736 | 0.88 | TTK (1.00) | ALKTTKFESFLT3ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ERBB4, EGFR, ALK | ALK 3/4885TTK 333/4885FES 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.