Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CCR7 | P32248 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487064 | 0.89 | CXCR2 (0.46) | CXCR2CXCR1 | |
| SCHEMBL1487018 | 0.89 | CXCR2 (0.46) | CXCR2CXCR1 | |
| SCHEMBL12153017 | 0.87 | CXCR2 (0.45) | CXCR2CXCR1 | |
| SCHEMBL1803591 | 0.86 | CXCR2 (0.36) | CXCR2CXCR1CCR7 | |
| SCHEMBL1487137 | 0.85 | CXCR2 (0.53) | CXCR2CXCR1 | |
| SCHEMBL1487141 | 0.85 | CXCR2 (0.53) | CXCR2CXCR1 | |
| SCHEMBL1803298 | 0.83 | CXCR2 (0.62) | CXCR2CXCR1 | |
| SCHEMBL1804986 | 0.83 | CXCR2 (0.46) | CXCR2CXCR1 | |
| SCHEMBL1799348 | 0.81 | CXCR2 (0.40) | CXCR2CXCR1 | |
| SCHEMBL1806813 | 0.81 | CXCR2 (0.41) | CXCR2CXCR1CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301933-A1 | Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |