Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | KAT7 | O95251 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487172 | 1.00 | CXCR2 (0.50) | CXCR2CXCR1GPR119MAPTSMN1; SMN2 | |
| SCHEMBL1644205 | 0.91 | CXCR2 (0.53) | CXCR2CXCR1 | |
| SCHEMBL1487391 | 0.91 | CXCR2 (0.53) | CXCR2CXCR1 | |
| SCHEMBL1487112 | 0.88 | CXCR2 (0.59) | CXCR2CXCR1GPR119MAPTSMN1; SMN2 | |
| SCHEMBL1646054 | 0.86 | CXCR2 (0.62) | CXCR2CXCR1GPR119MAPTSMN1; SMN2 | |
| SCHEMBL1487173 | 0.82 | CXCR2 (0.51) | CXCR2CXCR1 | |
| SCHEMBL1487240 | 0.82 | CXCR2 (0.51) | CXCR2CXCR1 | |
| SCHEMBL1486995 | 0.82 | CXCR2 (0.58) | CXCR2CXCR1GPR119MAPTSMN1; SMN2 | |
| SCHEMBL1487215 | 0.81 | CXCR2 (0.57) | CXCR2CXCR1MAPT | |
| SCHEMBL9972769 | 0.81 | CXCR2 (0.53) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311827-A1 | Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators. | AstraZeneca AB (SE) | 2011-04-20 | — | — | EP | disclosed |
| EP-2301933-A1 | Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |