Luseogliflozin

Luseogliflozin

SCHEMBL1487519

CCOc1ccc(Cc2cc([C@@H]3S[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)cc2C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 19/20 1.00
SLC5A1 P13866 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Luseogliflozin SCHEMBL16155082 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL18265378 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL27177461 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL900678 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL29355402 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL18629765 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL16153589 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
Luseogliflozin SCHEMBL17278233 1.00 SLC5A2 (1.00) SLC5A2SLC5A1
SCHEMBL903229 0.93 SLC5A2 (0.87) SLC5A2SLC5A1
SCHEMBL17189390 0.93 SLC5A2 (0.87) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230000816-A1 SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITORS FOR THE MANAGEMENT OF CHRONIC KIDNEY DISEASE, HYPERTENSION, AND HEART FAILURE IN COMPANION ANIMALS INCREVET, INC. 2023-01-05 US claimed
WO-2022117893-A2 COMBINATION THERAPY FOR PATIENTS HAVING ACUTE AND/OR PERSISTENT DYSPNEA S-FORM PHARMA (BE) 2022-06-09 WO claimed
US-20110077212-A1 THERAPEUTIC USES OF SGLT2 INHIBITORS THERACOS, INC. (US) 2011-03-31 US claimed
US-20240009167-A1 AGENT FOR ELIMINATING SENESCENT CELLS NIIGATA UNIVERSITY (JP) 2024-01-11 US disclosed
US-20230381101-A1 AQUEOUS PHARMACEUTICAL COMPOSITIONS COMPRISING SGLT-2 INHIBITORS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-11-30 US disclosed
US-20230372375-A1 SGLT-2 INHIBITOR SARCOSINE CO-CRYSTAL, PREPARATION METHOD THEREFOR AND USE THEREOF OMNISINO HEALTH (TIANJIN) MEDICAL TECHNOLOGY CO. LTD (CN) 2023-11-23 US disclosed
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor HUA MEDICINE (SHANGHAI) LTD. (CN) 2023-11-14 US disclosed
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor HUA MEDICINE (SHANGHAI) LTD. (CN) 2023-11-14 US disclosed
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor HUA MEDICINE (SHANGHAI) LTD. (CN) 2023-11-14 US disclosed
US-11813244-B2 Agent for eliminating senescent cells NIIGATA UNIVERSITY (JP) 2023-11-14 US disclosed
US-20230331760-A1 ARYL GLUCOSIDE DERIVATIVE AND USE THEREOF IN DRUG SHANGHAI ZHEYE BIOTECHNOLOGY CO. LTD. (CN) 2023-10-19 US disclosed
US-8017792-B2 1-thio-D-glucitol derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-13 US disclosed
US-8017792-B2 1-thio-D-glucitol derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-13 US disclosed
US-20110098469-A1 1-THIO-D-GLUCITOL DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-04-28 US disclosed
US-20110098469-A1 1-THIO-D-GLUCITOL DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-04-28 US disclosed
US-20110077212-A1 THERAPEUTIC USES OF SGLT2 INHIBITORS THERACOS, INC. (US) 2011-03-31 US disclosed
US-7910619-B2 e.g. 2,3,4,6-tetra-O-benzyl-5-thio-D-glucono-1,5-lactone3,4-Dihydro-2H-pyran; inhibit the activity of sodium-dependent glucose cotransporter 2 (SGLT2) concerned with glucose reabsorption in the kidney; antidiabetic agent; diabetes-related disease, or diabetic complication TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-03-22 US disclosed
US-7910619-B2 e.g. 2,3,4,6-tetra-O-benzyl-5-thio-D-glucono-1,5-lactone3,4-Dihydro-2H-pyran; inhibit the activity of sodium-dependent glucose cotransporter 2 (SGLT2) concerned with glucose reabsorption in the kidney; antidiabetic agent; diabetes-related disease, or diabetic complication TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-03-22 US disclosed
US-20080132563-A1 1-Thio-D-Glucitol Derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-06-05 US disclosed
US-20080132563-A1 1-Thio-D-Glucitol Derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-06-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230372375-A1 SGLT-2 INHIBITOR SARCOSINE CO-CRYSTAL, PREPARATION METHOD THEREFOR AND USE THEREOF SLC5A2, SLC5A1, SLC2A2 SLC5A2 1/4885SLC5A1 2/4885
US-20110098469-A1 1-THIO-D-GLUCITOL DERIVATIVES SLC5A1, SLC5A2, SLC5A11 SLC5A2 2/4885SLC5A1 1/4885
US-20110077212-A1 THERAPEUTIC USES OF SGLT2 INHIBITORS SLC5A2, SLC5A1, PPARG SLC5A2 1/4885SLC5A1 2/4885
US-20230331760-A1 ARYL GLUCOSIDE DERIVATIVE AND USE THEREOF IN DRUG SLC5A1, SLC5A2, SLC10A1 SLC5A2 2/4885SLC5A1 1/4885
US-11813274-B2 Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor SLC5A2, SLC5A1, SLC2A1 SLC5A2 1/4885SLC5A1 2/4885
US-20230381101-A1 AQUEOUS PHARMACEUTICAL COMPOSITIONS COMPRISING SGLT-2 INHIBITORS SLC5A2, SLC5A1, SLC2A2 SLC5A2 1/4885SLC5A1 2/4885
US-20080132563-A1 1-Thio-D-Glucitol Derivatives SLC5A1, SLC5A2, SLC5A11 SLC5A2 2/4885SLC5A1 1/4885
US-20230000816-A1 SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITORS FOR THE MANAGEMENT OF CHRONIC KIDNEY DISEASE, HYPERTENSION, AND HEART FAILURE IN COMPANION ANIMALS SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.