Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.76 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.76 |
| ▸ | CTSD | P07339 | 3/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384469 | 0.89 | BACE1 (0.73) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL15510499 | 0.88 | BACE1 (0.69) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2372030 | 0.88 | BACE1 (0.68) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2372377 | 0.88 | BACE1 (0.71) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2372373 | 0.88 | BACE1 (0.71) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2381866 | 0.88 | BACE1 (0.75) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2019582 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2370984 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2013687 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL15509653 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |