Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878062 | 0.89 | BACE1 (0.63) | BACE1CTSD | |
| SCHEMBL15510174 | 0.81 | BACE1 (0.57) | BACE1CTSD | |
| SCHEMBL2010854 | 0.81 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL14877612 | 0.79 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL14877632 | 0.79 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2384342 | 0.79 | BACE1 (0.75) | BACE1CTSD | |
| SCHEMBL2012103 | 0.79 | BACE1 (0.72) | BACE1CTSD | |
| SCHEMBL14878048 | 0.78 | BACE1 (0.71) | BACE1CTSD | |
| SCHEMBL15510108 | 0.78 | BACE1 (0.69) | BACE1CTSD | |
| SCHEMBL2384172 | 0.76 | BACE1 (0.60) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |