Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877610 | 1.00 | MAPT (0.36) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13928179 | 0.91 | MAPT (0.35) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13928178 | 0.91 | MAPT (0.35) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13928180 | 0.90 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13928177 | 0.90 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13950821 | 0.88 | MAPT (0.34) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13928164 | 0.87 | MAPT (0.39) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL3251345 | 0.87 | KDM4E (0.38) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3254799 | 0.87 | MAPT (0.38) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13950882 | 0.85 | KDM4E (0.38) | MAPTLMNATP53KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |