Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | CTSD | P07339 | 16/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011657 | 0.88 | BACE1 (0.73) | BACE1KCNH2CTSD | |
| SCHEMBL15509848 | 0.87 | BACE1 (0.63) | BACE1KCNH2CTSD | |
| SCHEMBL14877632 | 0.85 | BACE1 (0.60) | BACE1KCNH2CTSD | |
| SCHEMBL15510358 | 0.85 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL14877626 | 0.84 | BACE1 (0.60) | BACE1KCNH2CTSD | |
| SCHEMBL15509598 | 0.84 | BACE1 (0.77) | BACE1KCNH2CTSD | |
| SCHEMBL2380883 | 0.83 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL2521389 | 0.83 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL15510113 | 0.81 | BACE1 (0.75) | BACE1KCNH2CTSD | |
| SCHEMBL14877627 | 0.80 | BACE1 (0.74) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |