Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.64 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.51 |
| ▸ | CTSD | P07339 | 2/20 | 0.51 |
| ▸ | CTSE | P14091 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15509832 | 0.86 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL15510224 | 0.86 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL2012008 | 0.86 | BACE1 (0.74) | BACE1KCNH2CTSD | |
| SCHEMBL13401352 | 0.86 | BACE1 (0.74) | BACE1KCNH2BACE2CTSDCTSE | |
| SCHEMBL6845279 | 0.86 | BACE1 (0.74) | BACE1KCNH2BACE2CTSDCTSE | |
| SCHEMBL15510520 | 0.86 | BACE1 (0.74) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15510521 | 0.86 | BACE1 (0.74) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15510171 | 0.85 | BACE1 (0.65) | BACE1KCNH2BACE2CTSDCTSE | |
| SCHEMBL15510168 | 0.85 | BACE1 (0.65) | BACE1KCNH2BACE2CTSDCTSE | |
| SCHEMBL1993524 | 0.85 | BACE1 (0.75) | BACE1KCNH2BACE2CTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |