Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531783 | 0.90 | BTK (0.47) | BTK | |
| SCHEMBL13547714 | 0.82 | BTK (0.49) | BTK | |
| SCHEMBL13531786 | 0.81 | BTK (0.39) | BTK | |
| SCHEMBL14878003 | 0.79 | BTK (0.48) | BTK | |
| SCHEMBL13526956 | 0.76 | BTK (0.53) | BTK | |
| SCHEMBL13531806 | 0.76 | EPHB4 (0.33) | BTK | |
| SCHEMBL14878015 | 0.75 | BTK (0.33) | BTK | |
| SCHEMBL3176399 | 0.73 | BTK (0.60) | BTK | |
| SCHEMBL1542513 | 0.71 | BTK (0.57) | BTK | |
| SCHEMBL1542725 | 0.71 | BTK (0.68) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426409-B2 | 7-tert-Butyl-3-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-3H-quinazolin-4-one; arthritis; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | disclosed |