Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.37 |
| ▸ | PIM1 | P11309 | 7/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.33 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531792 | 0.92 | BTK (0.44) | BTKPIM1PIM2PIM3SYK | |
| SCHEMBL13531794 | 0.73 | AURKA (0.41) | BTKSYK | |
| SCHEMBL1542550 | 0.69 | BTK (0.51) | BTKSYK | |
| SCHEMBL14878009 | 0.68 | AURKA (0.41) | BTKPIM1PIM2PIM3EPHB4 | |
| SCHEMBL13531803 | 0.68 | BTK (0.61) | BTK | |
| SCHEMBL8736925 | 0.67 | BTK (0.65) | BTKJAK2 | |
| SCHEMBL13531793 | 0.66 | BTK (0.46) | BTKEPHB4SYK | |
| SCHEMBL14878003 | 0.65 | BTK (0.48) | BTK | |
| SCHEMBL13531804 | 0.65 | BTK (0.51) | BTK | |
| SCHEMBL13531801 | 0.64 | BTK (0.40) | BTKPIM1PIM2EPHB4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426409-B2 | 7-tert-Butyl-3-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-3H-quinazolin-4-one; arthritis; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | disclosed |